synthetic strategies

The Department of Syntheses at the Institute of Inorganic Chemistry of the Czech Academy of Sciences has historically focused on boron cluster chemistry. We continue this legacy and strive to bring modern tools and the latest techniques to this area of chemistry.

Our group focuses mainly on carboranes and metallacarboranes. The first step is always a precisely targeted cluster activation either on carbon or boron. The next step is the derivatization of the functional groups just formed and their subsequent utilization. [boron clusters in the synthesis]

Our group is currently focusing on the use of carboranes and metallacarboranes in cross-coupling reactions such as Suzuki or Buchwald-Hartwig couplings but also on the use of these compounds in free-radical reactions and photochemistry. Other methods are cycloadditions with carboryne, a carborane analog of benzyne. Of course, various substitution reactions of aliphatic chains connected to boron clusters are necessary. 

The long-term goal is to prepare new boron cluster derivatives and their bioisosteres that can be applied in medicinal chemistry, such as new antibiotics, mitochondrial uncouplers, or cancer treatment.